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Year Number of Results
2001 2
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2003 4
2004 9
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2008 8
2009 13
2010 27
2011 32
2012 34
2013 31
2014 39
2015 47
2016 45
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566 results

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Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.
De Simone V, Franzè E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D, Sica GS, Sileri P, MacDonald TT, Pallone F, Monteleone G, Stolfi C. De Simone V, et al. Oncogene. 2015 Jul;34(27):3493-503. doi: 10.1038/onc.2014.286. Epub 2014 Sep 1. Oncogene. 2015. PMID: 25174402 Free PMC article.
Herein, we isolate tumor-infiltrating leukocytes (TILs) and lamina propria mononuclear cells (LPMCs) from the tumor area and the macroscopically unaffected, adjacent, colonic mucosa of patients who underwent resection for sporadic CRC and show that the culture supernatants of TIL …
Herein, we isolate tumor-infiltrating leukocytes (TILs) and lamina propria mononuclear cells (LPMCs) from the tumor area and the macroscopic …
IL-17 and Th17 Cells.
Korn T, Bettelli E, Oukka M, Kuchroo VK. Korn T, et al. Annu Rev Immunol. 2009;27:485-517. doi: 10.1146/annurev.immunol.021908.132710. Annu Rev Immunol. 2009. PMID: 19132915 Review.
The differentiation factors (TGF-beta plus IL-6 or IL-21), the growth and stabilization factor (IL-23), and the transcription factors (STAT3, RORgammat, and RORalpha) involved in the development of Th17 cells have just been identified. ...
The differentiation factors (TGF-beta plus IL-6 or IL-21), the growth and stabilization factor (IL-23), and the transcription …
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.
Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, Hanash AM. Lindemans CA, et al. Nature. 2015 Dec 24;528(7583):560-564. doi: 10.1038/nature16460. Epub 2015 Dec 9. Nature. 2015. PMID: 26649819 Free PMC article.
The intestinal stem cell (ISC) niche provides Wnt, Notch and epidermal growth factor (EGF) signals supporting Lgr5(+) crypt base columnar ISCs for normal epithelial maintenance. ...Recombinant IL-22 directly targeted ISCs, augmenting the growth of both mouse and human inte …
The intestinal stem cell (ISC) niche provides Wnt, Notch and epidermal growth factor (EGF) signals supporting Lgr5(+) crypt base colu …
Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.
Yang W, Yu T, Huang X, Bilotta AJ, Xu L, Lu Y, Sun J, Pan F, Zhou J, Zhang W, Yao S, Maynard CL, Singh N, Dann SM, Liu Z, Cong Y. Yang W, et al. Nat Commun. 2020 Sep 8;11(1):4457. doi: 10.1038/s41467-020-18262-6. Nat Commun. 2020. PMID: 32901017 Free PMC article.
SCFAs upregulate IL-22 production by promoting aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1alpha (HIF1alpha) expression, which are differentially regulated by mTOR and Stat3. HIF1alpha binds directly to the Il22 promoter, and SCFAs increase …
SCFAs upregulate IL-22 production by promoting aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1alpha (HIF1alpha) expres …
IL22 drives cutaneous melanoma cell proliferation, migration and invasion through activation of miR-181/STAT3/AKT axis.
He Y, Yang Y, Xu J, Liao Y, Liu L, Deng L, Xiong X. He Y, et al. J Cancer. 2020 Feb 19;11(9):2679-2687. doi: 10.7150/jca.40974. eCollection 2020. J Cancer. 2020. PMID: 32201538 Free PMC article.
Finally, in CM cells deriving from different culture history, we identified STAT3 to be a target gene of miR-181. Higher expression level of IL22 suppressed STAT3 expression, while enhanced expression of p-AKT, p-beta-catenin and MMP4; however, down-regulatio …
Finally, in CM cells deriving from different culture history, we identified STAT3 to be a target gene of miR-181. Higher expression l …
Fungal-induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL-22.
Zhu Y, Shi T, Lu X, Xu Z, Qu J, Zhang Z, Shi G, Shen S, Hou Y, Chen Y, Wang T. Zhu Y, et al. EMBO J. 2021 Jun 1;40(11):e105320. doi: 10.15252/embj.2020105320. Epub 2021 Feb 16. EMBO J. 2021. PMID: 33591591 Free PMC article.
IL-7 induced IL-22 production in RORgammat(+) (group 3) innate lymphoid cells (ILC3s) via aryl hydrocarbon receptor and STAT3. Consistently, IL-22 frequency in tumor tissues of colon cancer patients positively correlated with fungal burden, indicating the relevance of this …
IL-7 induced IL-22 production in RORgammat(+) (group 3) innate lymphoid cells (ILC3s) via aryl hydrocarbon receptor and STAT3. Consis …
STAT3 and its activators in intestinal defense and mucosal homeostasis.
Hruz P, Dann SM, Eckmann L. Hruz P, et al. Curr Opin Gastroenterol. 2010 Mar;26(2):109-15. doi: 10.1097/MOG.0b013e3283365279. Curr Opin Gastroenterol. 2010. PMID: 20040863 Review.
Similarly, IL-6, secreted by macrophages, dendritic cells, epithelial cells, and T cells protects against mucosal damage, but it is also key in the development of Th17 cells, which mediate inflammatory and defensive responses in the intestine. Both cytokines activate STAT3 …
Similarly, IL-6, secreted by macrophages, dendritic cells, epithelial cells, and T cells protects against mucosal damage, but it is also key …
Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis.
Furue M. Furue M. Int J Mol Sci. 2020 Jul 29;21(15):5382. doi: 10.3390/ijms21155382. Int J Mol Sci. 2020. PMID: 32751111 Free PMC article. Review.
IL-4 and IL-13 potently inhibit the expression of these molecules by activating signal transducer and activator of transcription (STAT)6 and STAT3. In addition to IL-4 and IL-13, IL-22 and IL-17A are probably involved in the barrier dysfunction by inhibiting the exp …
IL-4 and IL-13 potently inhibit the expression of these molecules by activating signal transducer and activator of transcription (STA …
Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy.
Pavlidis P, Tsakmaki A, Pantazi E, Li K, Cozzetto D, Digby-Bell J, Yang F, Lo JW, Alberts E, Sa ACC, Niazi U, Friedman J, Long AK, Ding Y, Carey CD, Lamb C, Saqi M, Madgwick M, Gul L, Treveil A, Korcsmaros T, Macdonald TT, Lord GM, Bewick G, Powell N. Pavlidis P, et al. Nat Commun. 2022 Oct 3;13(1):5820. doi: 10.1038/s41467-022-33331-8. Nat Commun. 2022. PMID: 36192482 Free PMC article.
IL-22-mediated transcriptional regulation of CXC-family neutrophil-active chemokine expression is highly conserved across species, is dependent on STAT3 signaling, and is functionally and pathologically important in the recruitment of CXCR2(+) neutrophils into colonic tiss …
IL-22-mediated transcriptional regulation of CXC-family neutrophil-active chemokine expression is highly conserved across species, is depend …
Recent Developments on the Crosstalk Between STAT3 and Inflammation in Heart Function and Disease.
Kurdi M, Zgheib C, Booz GW. Kurdi M, et al. Front Immunol. 2018 Dec 19;9:3029. doi: 10.3389/fimmu.2018.03029. eCollection 2018. Front Immunol. 2018. PMID: 30619368 Free PMC article. Review.
The transcription factor STAT3 has a protective function in the heart. Until recently, the role of STAT3 in hypertension-induced cardiac hypertrophy was unsettled. ...Besides canonical signaling pathways, unphosphorylated STAT3 (U-STAT3) …
The transcription factor STAT3 has a protective function in the heart. Until recently, the role of STAT3 in hype …
566 results